A therapeutic evaluation of various modalities of treatment of keloid-A randomized open label study

Keloid and hypertrophic scar are the result of abnormal growth fibrous tissue following healing a cutaneous injury in predisposed individuals. Some treatment options pressure garments, radiation therapy, excision, intralesional injections, cryotherapy, silicone gel dressing lasers though no single modality is completely effective. To study efficacy, to compare adverse effects 4 different modalities keloid namely, Intralesional triamcinolone acetonide (TAC), 5-fluoro uracil (5-FU), sheet (SGS) Radiofrequency (RF). Arandomized open label was conducted dermatology department tertiary care hospital Gujarat from Nov 2020 December 2022. 108 patients were allocated groups, Group 1(TAC), 2( + 5FU), 3( SGS) 4(RF). 1 received injections Triamcinolone (alone), 2 5- fluorouracil, 3 given topical treated with radiofrequency. A total age group 18-52 years enrolled divided into groups consisting 27 each Improvement pliability, vascularity, pigmentation height maximum TAC 5FU least SGS group. At end weeks, excellent improvement found highest 29.6% TAC+5FU group, 22.2% alone, 18.5% RF 11.1% TAC+SGS 8 51.8% 44.4% 40.7% 25.9% The difference statistically significant.Skin atrophy, telangiectasia, hypopigmentation recurrence observed more therapies whereas, ulceration infection frequent treatment, however few cases also seen In this terms pliability overall response 5 FU